Science and Law
4th August 2015

Are You Up-To-Date on E-cigarette Science?

The advancing pace of the science related to e-cigarettes is staggering. Dozens of studies are being published every week related to the safety and/or efficacy of e-cigarettes. The rapid pace of emerging science makes it a challenge for some to keep up with the latest research findings which can forecast potential liability issues that may unfold.

Are You Up-To-Date on E-cigarette Science?

If you have an interest in potential liability issues related to e-cigarettes – that is, you are an e-cigarette manufacturer or a lawyer defending a manufacturer- it is critical to stay aware and up-to-date on the emerging science.

The advancing pace of the science related to e-cigarettes is staggering. Dozens of studies are being published every week related to the safety and/or efficacy of e-cigarettes. The rapid pace of emerging science makes it a challenge for some to keep up with the latest research findings which can forecast potential liability issues that may unfold.

Whether you are an e-cigarette manufacturer, or counsel representing e-cigarette manufacturers, it is critical to stay abreast of the relevant scientific developments so you can anticipate potential health and/or promotional issues, as well as defend yourself from being caught off-guard or ambushed with science that may impact your business or client.

While staying up-to-date on the latest science can be time-consuming, one key to keeping fresh with the science is to develop a systematic process to evaluate the new developments. At ISS, we have been tracking the e-cigarette science closely over the past year. See our previous posts about the safety and efficacy of e-cigarettes, the potential health effects of e-cigarettes, the importance of tracking e-cigarette science and legal implications related to e-cigarettes.

Below we provide a small sample of e-cigarette scientific studies published in the past month alone:

Potential Health Effects

E-cigarettes generate high levels of aldehydes only in ‘dry puff’ conditions.

This study aimed to evaluate aldehyde emissions at various power levels associated with normal and dry puff conditions, in which the liquid overheats. Investigators found that e- cigarettes produce high levels of aldehyde only in dry puff conditions. Under normal vaping conditions aldehyde emissions were minimal.

Nicotine and the Developing Human: A Neglected Element in the Electronic Cigarette Debate.

Authors use human and animal data to support that e-cigarette exposures have adverse health consequences on pregnant women. The report proposes specific public health regulations of e-cigarettes that could be implemented to protect the health of vulnerable populations.

Effectiveness as Smoking Cessation Instruments

Science and the evolving electronic cigarette.

While existing literature has examined e-cigarettes in association with user puffing behavior, physiological effects, abuse liability and effects on smoking cessation, researchers suggest that there is a gap in literature on the evaluation of newer e-cigarette devices. The report emphasizes the importance of gaining a better understanding of more current e-cigarette models and their effects.

Electronic Cigarettes: The nicotyrine hypothesis.

Researchers propose that e-cigarette users are exposed to significant levels of serum nicotine when they inhale nicotine and nicotyrine together. Because nicotyrine reversibly inhibits nicotine metabolism by CYP2A13, achieving high levels of serum would delay nicotine delivery. Therefore, investigators suggest that CYP2A inhibitors, such as nicotyrine, may be effective in smoking cessation therapy.

Electronic Cigarettes Efficacy and Safety at 12 Months: Cohort Study.

In order to evaluate the efficacy of e-cigarettes as a smoking cessation tool, investigators compared users of e-cigarettes, smokers of tobacco cigarettes and smokers of both. Study results showed that the addition of e-cigarettes to tobacco smoking did not facilitate smoking cessation or reduction.

Perception Studies

Smokers’ and ex-smokers’ understanding of electronic cigarettes: a qualitative study.

Focus groups and individual interviews were conducted to explore how nicotine-containing products, particularly e-cigarettes, are understood and experienced by users. The qualitative study revealed that many users are unaware of the benefits and/or risks associated with e-cigarette use.

Reasons for Electronic Cigarette Experimentation and Discontinuation Among Adolescents and Young Adults.

Investigators carried out focus groups to gain a better understanding of e-cigarette experimentation and discontinuation by young people. Authors suggest that the study conclusions can be utilized to address e-cigarette prevention efforts, including limiting flavors, communicating the health risks of e-cig use and changing social norms surrounding the use of e-cigarettes.

As the science relating to e-cigarettes continues to emerge and mature, it is vital that manufacturers and their attorneys consider the potential liability issues that may arise. While rigorously tracking such a new scientific area can be daunting, we have developed a tool that can help you do this effectively and efficiently.

DataTrove is designed specifically to leverage subject matter experts who are well versed in science to target and filter through the hundreds or thousands of pieces of scientific literature to find and deliver the information that’s most relevant to you.

You and your team will be armed with a library of timely, relevant information keeping you abreast of developing e-cigarette science to protect you or your client from being caught off-guard, as well as to harness important and helpful findings from the available science.

Receive weekly updates on e-cigarette science right to your email through our original data curation system, DataTrove.

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