Science and Law
6th November 2014

Keeping Up with Asbestos Science is Hard!

The constant stream of newly published asbestos studies makes it difficult for some legal teams to keep abreast of the developing science, which is critical to help protect you and your client from being caught off-guard (during cross-examination, or you may even miss a chance to discredit your opposition).

Keeping Up with Asbestos Science is Hard!

The science related to asbestos health effects is emerging at break-neck speed.

The constant stream of newly published asbestos studies makes it difficult for some legal teams to keep abreast of the developing science, which is critical to help protect you and your client from being caught off-guard (during cross-examination, or you may even miss a chance to discredit your opposition).

Scientists continue to push the boundaries when it comes to asbestos-related studies. For instance, we’ve noticed that biomarkers (e.g. miRNAs, proteins, and exhaled breath) are showing great promise as diagnostic and prognostic aids for mesothelioma, as well as to help measure asbestos exposures. Undoubtedly, as the biomarker science matures, other uses for these biomarkers will certainly emerge.

In addition to asbestos biomarker science, there is a constant stream of more traditional science being published, including case reports, epidemiological studies, mechanistic studies, and population genetic studies. And this is in addition to grants, clinical trials, blogs, and popular news.

Here is just a small sample of studies to give you a flavor of the types of asbestos-related studies that were published in the past few weeks to months (click the links to go the Pubmed abstract):

Diagnostic Tools

Newly established ELISA for N-ERC/mesothelin improves diagnostic accuracy in patients with suspected pleural mesothelioma.
Role of microRNAs in malignant mesothelioma.

Biomarker Studies

Formation of the Nitrative DNA Lesion 8-Nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Study.
Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma.

Epidemiological Studies

Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis.
Asbestos in commercial cosmetic talcum powder as a cause of mesothelioma in women.

Mechanistic Studies

Mode of action of fibrous amphiboles: the case of Biancavilla (Sicily, Italy).
Chronic exposure to asbestos enhances TGF-β1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2.

Population Genetics

Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area.

At ISS, we have scientists that have mastered monitoring the asbestos literature, and we’ve designed a tool to help us do it even better. We call it DataTrove. Give it a try by signing up for your free 1-month trial, and you’ll get a summary of the latest asbestos science in your inbox once per week.

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